E.E.T.-Pipeline

European Embryonal Tumor Pipeline

 

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© 2007

Freund/OncoLab

institutCurie

 

The group

The group of »Genetics and biology of pædiatric cancers« is studying the role of genetic alterations in the development of childhood cancers and particularly the Ewing tumour, rhabdoid tumour and neuroblastoma with more recent interest in rhabdomyosarcoma and medulloblastoma. The group is using microarray approaches (array-CGH, SNP, expression profiling) to investigate the genetic profiles of these cancers. A particular interest is focussing on the role of the EWS/FLI fusion in oncogenesis of the Ewing tumour and on the role of the loss of function of hSNF5/INI1 in the development of rhabdoid tumours.

 

Our role in EET-Pipeline

Within the EET-Pipeline, the group will mainly contribute to research on malignant rhabdoid tumours, a rare but extremely aggressive cancer of early childhood. More specifically, we propose to set up diagnostic tools for the diagnosis of malignant rhabdoid tumours, to analyse the cellular origin of the MRT progenitor using mRNA and microRNA transcription profiles and in vitro or in vivo differentiation experiments. Finally, our study will also concentrate on putative therapeutic targets which may be involved in cell cycle or differentiation regulation.

 

Staff Member

 

Top 5 publications

1. Versteege, I, Medjkane, S, Rouillard, D, Delattre, O. A key role of the hSNF5/INI1 tumour suppressor in the control of the G1-S transition of the cell cycle. Oncogene 21, 6403-6412, 2002.

2. Medjkane, S., Novikov, E., Versteege, I., Delattre, O. The tumour suppressor SNF5/INI1 modulates cell growth and actin cytoskeleton organization. Cancer Research, 64: 3406-3413, 2004.

3. Prieur, A., Tirode, F., Cohen, P., Delattre. O. EWS/FLI-1 silencing and gene profiling of Ewing cells reveals downstream oncogenic pathways and a crucial role for repression of IGFBP-3. Mol Cell Biol, 24 :7275-7283, 2004.

4. Bourdeaut F, Fréneaux P, Thuille B, Lellouch-Tubiana A, Nicolas A, Couturier J, Pierron G, Sainte-Rose C, Bergeron C, Bouvier R, Rialland X, Laurence V, Michon J, Sastre-Garau X, Delattre O. hSNF5/INI1-deficient tumours and rhabdoid tumours, two convergent but not fully overlapping entities. Journal of Pathology, 211 :323-330, 2007.

5. Tirode F, Laud-Duval K, Prieur A, Delorme B, Charbord P, Delattre O. Mesenchymal stem cell features of Ewing tumors. Cancer Cell. 2007 11(5):421-9.